USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: PHB2_HUMAN USC-OGP 2-DE database:  PHB2_HUMAN PHB2_HUMAN General information about the entry View entry in simple text format Entry name PHB2_HUMAN Primary accession number Q99623 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Prohibitin-2; AltName: Full=B-cell receptor-associated protein BAP37; AltName: Full=D-prohibitin; AltName: Full=Repressor of estrogen receptor activity;. Gene name Name=PHB2 {ECO:0000312|EMBL:AAH14766.1, ECO:0000312|HGNC:HGNC:30306} Synonyms=BAP {ECO:0000312|EMBL:AAB51324.1}, REA {ECO:0000312|EMBL:AAD38042.1} Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0982: pI=9.09; Mw=32933 Cross-references UniProtKB/Swiss-Prot Q99623; PHB2_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PHB2_HUMAN Primary accession number Q99623 Secondary accession number(s) B4DP75 Q2YDA4 Q7KYU3 Q92978 Sequence was last modified on  July 1, 1997 (version 2) Annotations were last modified on  March 15, 2017 (version 157) Name and origin of the protein Description RecName: Full=Prohibitin-2; AltName: Full=B-cell receptor-associated protein BAP37; AltName: Full=D-prohibitin; AltName: Full=Repressor of estrogen receptor activity; Gene name Name=PHB2 {ECO:0000312|EMBL:AAH14766.1, ECO:0000312|HGNC:HGNC:30306} Synonyms=BAP {ECO:0000312|EMBL:AAB51324.1}, REA {ECO:0000312|EMBL:AAD38042.1} Encoded on Name=PHB2 {ECO:0000312|EMBL:AAH14766.1, ECO:0000312|HGNC:HGNC:30306}; Synonyms=BAP {ECO:0000312|EMBL:AAB51324.1}, REA {ECO:0000312|EMBL:AAD38042.1 Keywords Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion inner membrane; Nucleus; Phosphoprotein; Receptor; Reference proteome; Repressor; Transcription; Transcription regulation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U72511; AAC51639.1; -; mRNA EMBL AF150962; AAD38042.1; -; mRNA EMBL AF178980; AAF44345.1; -; mRNA EMBL AF126021; AAF17231.1; -; mRNA EMBL AK298217; BAG60487.1; -; mRNA EMBL U47924; AAB51324.1; -; Genomic_DNA EMBL BC014766; AAH14766.1; -; mRNA EMBL BC110322; AAI10323.1; -; mRNA CCDS CCDS53741.1; -. [Q99623-1]; . CCDS CCDS58207.1; -. [Q99623-2]; . RefSeq NP_001138303.1; NM_001144831.1. [Q99623-1]; . RefSeq NP_001254629.1; NM_001267700.1. [Q99623-2]; . UniGene Hs.504620; -; . ProteinModelPortal Q99623; -; . SMR Q99623; -; . BioGrid 116459; 167; . IntAct Q99623; 69; . MINT MINT-142400; -; . STRING 9606.ENSP00000441875; -; . iPTMnet Q99623; -; . PhosphoSitePlus Q99623; -; . SwissPalm Q99623; -; . BioMuta PHB2; -; . DMDM 74752151; -; . OGP Q99623; -; . EPD Q99623; -; . MaxQB Q99623; -; . PaxDb Q99623; -; . PeptideAtlas Q99623; -; . PRIDE Q99623; -; . TopDownProteomics Q99623-1; -. [Q99623-1]; . TopDownProteomics Q99623-2; -. [Q99623-2]; . DNASU 11331; -; . Ensembl ENST00000440277; ENSP00000412856; ENSG00000215021. [Q99623-2]; . Ensembl ENST00000535923; ENSP00000441875; ENSG00000215021. [Q99623-1]; . GeneID 11331; -; . KEGG hsa:11331; -; . UCSC uc058kpb.1; human. [Q99623-1]; . CTD 11331; -; . DisGeNET 11331; -; . GeneCards PHB2; -; . HGNC HGNC:30306; PHB2; . HPA CAB014889; -; . HPA CAB026335; -; . HPA HPA039874; -; . MalaCards PHB2; -; . MIM 610704; gene; . neXtProt NX_Q99623; -; . OpenTargets ENSG00000215021; -; . PharmGKB PA142671181; -; . eggNOG KOG3090; Eukaryota; . eggNOG COG0330; LUCA; . GeneTree ENSGT00550000075076; -; . HOGENOM HOG000205692; -; . HOVERGEN HBG004457; -; . InParanoid Q99623; -; . KO K17081; -; . OMA SMAERMM; -; . OrthoDB EOG091G0IHW; -; . PhylomeDB Q99623; -; . TreeFam TF354230; -; . SIGNOR Q99623; -; . ChiTaRS PHB2; human; . GeneWiki PHB2; -; . GenomeRNAi 11331; -; . PRO PR:Q99623; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000215021; -; . CleanEx HS_PHB2; -; . ExpressionAtlas Q99623; baseline and differential; . Genevisible Q99623; HS; . GO GO:0071944; C:cell periphery; IDA:UniProtKB; . GO GO:0009986; C:cell surface; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; IDA:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB; . GO GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB; . GO GO:0005739; C:mitochondrion; IDA:UniProtKB; . GO GO:0016363; C:nuclear matrix; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0043234; C:protein complex; IDA:UniProtKB; . GO GO:0033218; F:amide binding; IPI:UniProtKB; . GO GO:0030331; F:estrogen receptor binding; NAS:UniProtKB; . GO GO:0008022; F:protein C-terminus binding; IPI:UniProtKB; . GO GO:0047485; F:protein N-terminus binding; IPI:UniProtKB; . GO GO:0060749; P:mammary gland alveolus development; IEA:Ensembl; . GO GO:0060744; P:mammary gland branching involved in thelarche; IEA:Ensembl; . GO GO:0007005; P:mitochondrion organization; IMP:UniProtKB; . GO GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB; . GO GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IEA:Ensembl; . GO GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Ensembl; . GO GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IMP:UniProtKB; . GO GO:0045892; P:negative regulation of transcription; DNA-templated; IDA:UniProtKB GO GO:1902808; P:positive regulation of cell cycle G1/S phase transition; IMP:UniProtKB; . GO GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB; . GO GO:0031536; P:positive regulation of exit from mitosis; IMP:UniProtKB; . GO GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; IDA:UniProtKB; . GO GO:0000060; P:protein import into nucleus; translocation; IDA:UniProtKB GO GO:0050821; P:protein stabilization; IMP:UniProtKB; . GO GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Ensembl; . GO GO:0007062; P:sister chromatid cohesion; IDA:UniProtKB; . GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW CDD cd03401; SPFH_prohibitin; 1; . InterPro IPR001107; Band_7; . InterPro IPR000163; Prohibitin; . PANTHER PTHR23222; PTHR23222; 1; . Pfam PF01145; Band_7; 1; . PRINTS PR00679; PROHIBITIN; . SMART SM00244; PHB; 1; . SUPFAM SSF117892; SSF117892; 1; .

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• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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